Which is a contraindication for the administration of tissue plasminogen activator (t-pa)?6/23/2023 However, observational studies are useful snapshots of the effect of a drug or therapy in the community setting. If so, the increased mortality rate with t-PA would be expected. Therefore, you have to ask if the patients who received t-PA had more severe strokes than those who did not. Bob: This study is a retrospective, observational study that was not randomized.
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